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But direct comparison is misleading for three reasons: Duration matters – weight loss compounds over time on these agents Population differences – baseline BMI and metabolic health vary between studies Trial phases differ – early-phase results are not designed to maximise outcomes In other words, these are not head-to-head results—they are snapshots at different stages of development
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The most frequently reported side effects remain gastrointestinal in nature, including nausea, diarrhoea, vomiting, and constipation
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